Fragmentation and Entanglement Limit Vimentin Intermediate Filament Assembly
نویسندگان
چکیده
Experiments and theoretical modeling show that disassembly of vimentin intermediate filaments---a key process in many biological cell functions---proceeds via filament breakage without the assistance other proteins.
منابع مشابه
Rupture mechanics of vimentin intermediate filament tetramers
Together with the globular proteins microtubules and microfilaments, intermediate filaments are one of the three major components of the cytoskeleton in eukaryotic cells. It consists of a dimeric coiled-coil building block, assembled in a very precise, hierarchical fashion into tetramers, forming filaments with characteristic dimensions on the order of several micrometers. Here we focus on the ...
متن کاملExpression of Vimentin Intermediate Filament Cytoskeleton
Since vimentin intermediate filament (IF) expression in hemopoietic cells varies with the cell lineage as well as the state of differentiation of the cells. we studied the vimentin cytoskeleton by direct immunofluorescence and electron microscopy in 50 cases of acute nonlymphocytic leukemias. We found that malignant cells tend to reproduce the vimentin organization characteristic of their norma...
متن کاملExpression of Vimentin Intermediate Filament Cytoskeleton in
Since vimentin intermediate filament (IF) expression in hemopoietic cells varies with the cell lineage as well as the state of differentiation of the cells. we studied the vimentin cytoskeleton by direct immunofluorescence and electron microscopy in 50 cases of acute nonlymphocytic leukemias. We found that malignant cells tend to reproduce the vimentin organization characteristic of their norma...
متن کاملNanomechanical properties of vimentin intermediate filament dimers.
The cell's cytoskeleton, providing the cell with structure and shape, consists of a complex array of structural proteins, including microtubules, microfilaments and intermediate filaments. Intermediate filaments play a crucial role in mechanotransduction and in providing mechanical stability to cells, in particular under large deformation. By utilizing molecular simulation, here we report a nan...
متن کاملAtomic structure of the vimentin central α-helical domain and its implications for intermediate filament assembly.
Together with actin filaments and microtubules, intermediate filaments (IFs) are the basic cytoskeletal components of metazoan cells. Over 80 human diseases have been linked to mutations in various IF proteins to date. However, the filament structure is far from being resolved at the atomic level, which hampers rational understanding of IF pathologies. The elementary building block of all IF pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physical Review X
سال: 2023
ISSN: ['2160-3308']
DOI: https://doi.org/10.1103/physrevx.13.011014